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Title:

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Document type:
Zeitschriftenaufsatz
Author(s):
Reinecke, Maria; Brear, Paul; Vornholz, Larsen; Berger, Benedict-Tilmann; Seefried, Florian; Wilhelm, Stephanie; Samaras, Patroklos; Gyenis, Laszlo; Litchfield, David William; Médard, Guillaume; Müller, Susanne; Ruland, Jürgen; Hyvönen, Marko; Wilhelm, Mathias; Kuster, Bernhard
Abstract:
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical probes to study kinase biology. Because of polypharmacology, a large part of the human kinome currently lacks selective chemical probes. To discover such probes, we profiled 1,183 compounds from drug discovery projects in lysates of cancer cell lines using Kinobeads. The resulting 500,000 compound-target interactions are available in ProteomicsDB a...     »
Keywords:
BayBioMS; Kinases, Proteomics, Small molecules, Target identification
Journal title:
Nature Chemical Biology
Year:
2023
Fulltext / DOI:
doi:10.1038/s41589-023-01459-3
Publisher:
Springer Science and Business Media LLC
E-ISSN:
1552-44501552-4469
Date of publication:
30.10.2023
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