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Title:

The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors

Document type:
Zeitschriftenaufsatz
Author(s):
Joachim, Laura; Göttert, Sascha; Sax, Anna; Steiger, Katja; Neuhaus, Klaus; Heinrich, Paul; Fan, Kaiji; Orberg, Erik Thiele; Kleigrewe, Karin; Ruland, Jürgen; Bassermann, Florian; Herr, Wolfgang; Posch, Christian; Heidegger, Simon; Poeck, Hendrik
Abstract:
Background: Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge in cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but the underlying molecular mechanisms remain unclear, and therapeutic modulation challenging. Methods: We established an in vivo model to treat C57Bl/6j mice with the type-I interferon (IFN-I)-modulating, bacterial-derived metabolite desaminotyrosine (DAT) to improve I...     »
Keywords:
BayBioMS; Antibiotics; Desaminotyrosine; Gut microbiome; Immune checkpoint inhibitors; Melanoma; Microbial metabolites
Journal title:
eBioMedicine
Year:
2023
Journal volume:
97
Pages contribution:
104834
Fulltext / DOI:
doi:10.1016/j.ebiom.2023.104834
Publisher:
Elsevier BV
E-ISSN:
2352-3964
Date of publication:
01.11.2023
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