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Title:

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

Document type:
Zeitschriftenaufsatz
Author(s):
von Strempel, Alexandra; Weiss, Anna S.; Wittmann, Johannes; Salvado Silva, Marta; Ring, Diana; Wortmann, Esther; Clavel, Thomas; Debarbieux, Laurent; Kleigrewe, Karin; Stecher, Bärbel
Abstract:
Gut microbial communities protect the host against a variety of major human gastrointestinal pathogens. Bacteriophages (phages) are ubiquitous in nature and frequently ingested via food and drinking water. Moreover, they are an attractive tool for microbiome engineering due to the lack of known serious adverse effects on the host. However, the functional role of phages within the gastrointestinal microbiome remain poorly understood. Here, we investigated the effects of microbiota-directed phages...     »
Keywords:
BayBioMS; Animals, Bacteriophages*; Escherichia coli; Gastrointestinal Microbiome*; Humans; Mice; Microbiota*; Salmonella Infections*; Salmonella Typhimurium
Journal title:
PLOS Pathogens
Year:
2023
Journal volume:
19
Journal issue:
8
Pages contribution:
e1011600
Fulltext / DOI:
doi:10.1371/journal.ppat.1011600
Publisher:
Public Library of Science (PLoS)
E-ISSN:
1553-7374
Date of publication:
21.08.2023
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