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Titel:

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
von Strempel, Alexandra; Weiss, Anna S.; Wittmann, Johannes; Salvado Silva, Marta; Ring, Diana; Wortmann, Esther; Clavel, Thomas; Debarbieux, Laurent; Kleigrewe, Karin; Stecher, Bärbel
Abstract:
Gut microbial communities protect the host against a variety of major human gastrointestinal pathogens. Bacteriophages (phages) are ubiquitous in nature and frequently ingested via food and drinking water. Moreover, they are an attractive tool for microbiome engineering due to the lack of known serious adverse effects on the host. However, the functional role of phages within the gastrointestinal microbiome remain poorly understood. Here, we investigated the effects of microbiota-directed phages...     »
Stichworte:
BayBioMS; Animals, Bacteriophages*; Escherichia coli; Gastrointestinal Microbiome*; Humans; Mice; Microbiota*; Salmonella Infections*; Salmonella Typhimurium
Zeitschriftentitel:
PLOS Pathogens
Jahr:
2023
Band / Volume:
19
Heft / Issue:
8
Seitenangaben Beitrag:
e1011600
Volltext / DOI:
doi:10.1371/journal.ppat.1011600
Verlag / Institution:
Public Library of Science (PLoS)
E-ISSN:
1553-7374
Publikationsdatum:
21.08.2023
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