Pauli, Theresa M.;Julius, Ayse;Costa, Francesco;Eschrig, Sabine;Moosmüller, Judith;Fischer, Lea;Schanzenbach, Christoph;Schmidt, Fabian C.;Ortner, Martin;Langosch, Dieter
Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach
International Journal of Molecular Sciences
2023
24
18
14396

Ortner, Martin;Guschtschin-Schmidt, Nadja;Stelzer, Walter;Muhle-Goll, Claudia;Langosch, Dieter
Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase
Journal of Molecular Biology
2023
435
18
168218

Schmidt, FabianC.;Fitz, Katja;Feilen, LukasP.;Okochi, Masayasu;Steiner, Harald;Langosch, Dieter
Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
Journal of Biological Chemistry
2023
104626

Werner, Nadine T.;Högel, Philipp;Güner, Gökhan;Stelzer, Walter;Wozny, Manfred;Aßfalg, Marlene;Lichtenthaler, Stefan F.;Steiner, Harald;Langosch, Dieter
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
Communications Biology
2023
6
1