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Document type:
Zeitschriftenaufsatz 
Author(s):
Linke, K., Periasamy, N., Ehrmann, M., Winter, R. and Vogel, R. F. 
Title:
Influence of high pressure on the dimerization of ToxR, a protein involved in bacterial signal transduction. 
Abstract:
High hydrostatic pressure (HHP) is suggested to influence the structure and function of membranes and/or integrated proteins. We demonstrate for the first time HHP-induced dimer dissociation of membrane proteins in vivo with Vibrio cholerae ToxR variants in Escherichia coli reporter strains carrying ctx:lacZ fusions. Dimerization ceased at 20 to 50 MPa depending on the nature of the transmembrane segments rather than on changes in the ToxR lipid bilayer environment. 
Keywords:
toxR 
Journal title:
Appl.Environ. Microbiol 
Year:
2008 
Journal volume:
74 
Journal issue:
24 
Pages contribution:
7821-3 
Language:
en 
Format:
Text