Hsp70 is a ubiquitously expressed protein with significance for protein folding, degradation, and cell cycle regulation. Various tumors express Hsp70 on the cell membrane. Gliomas (WHO-grade I-IV) are the most common primary brain tumors in adults. Glioma tissue (63 adult patients) was sampled using a novel monoclonal antibody (cmHsp70.1 mAb) to determine the membrane-bound Hsp70. Initially diagnosed WHO-grade II and III tumors had significantly higher membrane-bound Hsp70 percentages than WHO-grade IV tumors.
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Hsp70 is a ubiquitously expressed protein with significance for protein folding, degradation, and cell cycle regulation. Various tumors express Hsp70 on the cell membrane. Gliomas (WHO-grade I-IV) are the most common primary brain tumors in adults. Glioma tissue (63 adult patients) was sampled using a novel monoclonal antibody (cmHsp70.1 mAb) to determine the membrane-bound Hsp70. Initially diagnosed WHO-grade II and III tumors had significantly higher membrane-bound Hsp70 percentages than WHO-g...
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