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Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease.
Neuron
2025
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Kedia, Shreeya;Simons, Mikael
Oligodendrocytes in Alzheimer's disease pathophysiology.
Nat Neurosci
2025
28
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Flaskamp, Lavinia;Prechtl, Monica;Scheck, Annkathrin;Hu, Wenbo;Ried, Christine;Kislinger, Georg;Simons, Mikael;Krug, Anne B;Kranich, Jan;Brocker, Thomas
Assessing Extracellular Vesicle Turnover In Vivo Using Highly Sensitive Phosphatidylserine-Binding Reagents.
Adv Sci (Weinh)
2025
12
40

Tiwari, Vini;Simons, Mikael
Lipid metabolism and neuroinflammation: What is the link?
J Exp Med
2025
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Groh, Janos;Feng, Ruoqing;Yuan, Xidi;Liu, Lu;Klein, Dennis;Hutahaean, Gladis;Butz, Elisabeth;Wang, Zhen;Steinbrecher, Lisa;Neher, Jonas;Martini, Rudolf;Simons, Mikael
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration.
Nat Neurosci
2025
28
6
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Feng, Ruoqing;Spieth, Lena;Liu, Lu;Berghoff, Stefan;Franz, Jonas;Liu, Qian;Wang, Zhen;Tiwari, Vini;Vitale, Simona;Frerich, Simon;Florensa, Sergi;Junker, Niklas;Huber, Ludwig;Keller, Marco;Müller, Christoph;Bracher, Franz;Ge, Xiaoke;Rensen, Patrick C N;Kooij, Gijs;Hosang, Leon;Chornyi, Serhii;Dichgans, Martin;Gokce, Ozgun;Saher, Gesine;Stadelmann, Christine;Giera, Martin;Groh, Janos;Simons, Mikael
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions.
Immunity
2025
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12
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Rezaei, Ali;Kocsis-Jutka, Virág;Gunes, Zeynep I;Zeng, Qing;Kislinger, Georg;Bauernschmitt, Franz;Isilgan, Huseyin Berkcan;Parisi, Laura R;Kaya, Tuğberk;Franzenburg, Sören;Koppenbrink, Jonas;Knogler, Julia;Arzberger, Thomas;Farny, Daniel;Nuscher, Brigitte;Katona, Eszter;Dhingra, Ashutosh;Yang, Chao;Gouna, Garyfallia;LaClair, Katherine D;Janjic, Aleksandar;Enard, Wolfgang;Zhou, Qihui;Hagan, Nellwyn;Ofengeim, Dimitry;Beltrán, Eduardo;Gokce, Ozgun;Simons, Mikael;Liebscher, Sabine;Edbauer, Dieter
Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.
Nat Commun
2025
16
1

Simonetti, Francesca;Zhong, Weijia;Hutten, Saskia;Uliana, Federico;Schifferer, Martina;Rezaei, Ali;Ramirez, Lisa Marie;Hochmair, Janine;Sankar, Rithika;Gopalan, Anusha;Kielisch, Fridolin;Riemenschneider, Henrick;Ruf, Viktoria;Schmidt, Carla;Simons, Mikael;Zweckstetter, Markus;Wegmann, Susanne;Lashley, Tammaryn;Polymenidou, Magdalini;Edbauer, Dieter;Dormann, Dorothee
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
EMBO J
2025
44
24
7395-7433

Woo, Marcel S;Brand, Johannes;Bal, Lukas C;Moritz, Manuela;Walkenhorst, Mark;Vieira, Vanessa;Ipenberg, Inbal;Rothammer, Nicola;Wang, Man;Dogan, Batuhan;Loreth, Desirée;Mayer, Christina;Nagel, Darwin;Wagner, Ingrid;Pfeffer, Lena Kristina;Landgraf, Peter;van Ham, Marco;Mattern, Kuno M-J;Winschel, Ingo;Frantz, Noah;Sonner, Jana K;Grosshans, Henrike K;Miguela, Albert;Bauer, Simone;Meurs, Nina;Müller, Anke;Binkle-Ladisch, Lars;Salinas, Gabriela;Jänsch, Lothar;Dieterich, Daniela C;Riedner, Maria;Krüger, Elke;Heppner, Frank L;Glatzel, Markus;Puelles, Victor G;Engler, Jan Broder;Nyengaard, Jens Randel;Misgeld, Thomas;Kerschensteiner, Martin;Merkler, Doron;Meyer-Schwesinger, Catherine;Friese, Manuel A
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.
Cell
2025
188
17
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Woo, Marcel S;Brand, Johannes;Bal, Lukas C;Moritz, Manuela;Walkenhorst, Mark;Vieira, Vanessa;Ipenberg, Inbal;Rothammer, Nicola;Wang, Man;Dogan, Batuhan;Loreth, Desirée;Mayer, Christina;Nagel, Darwin;Wagner, Ingrid;Pfeffer, Lena Kristina;Landgraf, Peter;van Ham, Marco;Mattern, Kuno M-J;Winschel, Ingo;Frantz, Noah;Sonner, Jana K;Grosshans, Henrike K;Miguela, Albert;Bauer, Simone;Meurs, Nina;Müller, Anke;Binkle-Ladisch, Lars;Salinas, Gabriela;Jänsch, Lothar;Dieterich, Daniela C;Riedner, Maria;Krüger, Elke;Heppner, Frank L;Glatzel, Markus;Puelles, Victor G;Engler, Jan Broder;Nyengaard, Jens Randel;Misgeld, Thomas;Kerschensteiner, Martin;Merkler, Doron;Meyer-Schwesinger, Catherine;Friese, Manuel A
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.
Cell
2025
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