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Polyglutamylation of microtubules drives neuronal remodeling.
Nat Commun
2025
16
1

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Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation.
Immunity
2025
58
1
90-107.e11

Groh, Janos;Simons, Mikael
White matter aging and its impact on brain function.
Neuron
2025
113
1
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Neuroinflammation in Alzheimer disease.
Nat Rev Immunol
2025
25
5
321-352

Kaji, Seiji;Berghoff, Stefan A;Spieth, Lena;Schlaphoff, Lennart;Sasmita, Andrew O;Vitale, Simona;Büschgens, Luca;Kedia, Shreeya;Zirngibl, Martin;Nazarenko, Taisiia;Damkou, Alkmini;Hosang, Leon;Depp, Constanze;Kamp, Frits;Scholz, Patricia;Ewers, David;Giera, Martin;Ischebeck, Till;Wurst, Wolfgang;Wefers, Benedikt;Schifferer, Martina;Willem, Michael;Nave, Klaus-Armin;Haass, Christian;Arzberger, Thomas;Jäkel, Sarah;Wirths, Oliver;Saher, Gesine;Simons, Mikael
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.
Immunity
2025
58
1