Raj Murthi, Sarala;Petry, Andreas;Shashikadze, Bachuki;Stöckl, Jan B;Schmid, Manuel;Santamaria, Gianluca;Klingel, Karin;Kračun, Damir;Chen, Xinpei;Bauer, Sabine;Schmitt, Joachim P;Flenkenthaler, Florian;Gorham, Josh;Toepfer, Christopher N;Potěšil, David;Hruška, Pavel;Zdráhal, Zbyněk;Mayer, Zsuzsanna;Klop, Mathieu;Lehmann, Luisa;Qin, Yishi;Papanakli, Laura;Spielmann, Nadine;Moretti, Alessandra;Fröhlich, Thomas;Ewert, Peter;Holdenrieder, Stefan;Seidman, Jonathan G;Seidman, Christine E;Görlach, Agnes;Wolf, Cordula M
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.
Sci Rep
2025
15
1

Sohail, Iqra;Laurin, Suli-Anne;Kleinau, Gunnar;Chunilal, Vidicha;Morton, Andrew;Brenlla, Alfonso;Kagiali, Zeynep Cansu Uretmen;Blouin, Marie-José;Tello, Javier A;Beck-Sickinger, Annette G;Lohse, Martin J;Scheerer, Patrick;Bouvier, Michel;McCormick, Peter;Annibale, Paolo;Biebermann, Heike
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.
Nat Commun
2025
16
1

Mobach, Simon;Bergkamp, Nick D;Ma, Ziliang;Haselager, Marco V;Anbuhl, Stephanie M;Jurriens, Daphne;van den Bor, Jelle;Wang, Ziming;Crudden, Caitrin;Roos, Jamie L;Perez Almeria, Claudia V;Boergonje, Rick A;Lohse, Martin J;Bosma, Reggie;Eldering, Eric;Siderius, Marco;Wu, Wei;Spaargaren, Marcel;Tonino, Sanne H;Kater, Arnon P;Smit, Martine J;Heukers, Raimond
Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.
Proc Natl Acad Sci U S A
2025
122
24

Pan, Kylie S;Wang, Ziming;Pfeil, Cy;Bergkamp, Nick D;Mobach, Simon;Roth, Susanne;Rizk, Aurélien;Lohse, Martin J;Annibale, Paolo;Siderius, Marco;Zimmermann, Mirjam;Smit, Martine J;Bosma, Reggie
Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4.
Mol Pharmacol
2025
107
4

Ouologuem, Sarah;Martens, Laura D;Schaar, Anna C;Shulman, Maiia;Gagneur, Julien;Theis, Fabian J
Spatial transcriptomics deconvolution methods generalize well to spatial chromatin accessibility data.
Bioinformatics
2025
41
Supplement_1
i314-i322

Miyara, Shoval;Adler, Miri;Umansky, Kfir B;Häußler, Daniel;Bassat, Elad;Divinsky, Yalin;Elkahal, Jacob;Kain, David;Lendengolts, Daria;Ramirez Flores, Ricardo O;Bueno-Levy, Hanna;Golani, Ofra;Shalit, Tali;Gershovits, Michael;Weizman, Eviatar;Genzelinakh, Alexander;Kimchi, Danielle M;Shakked, Avraham;Zhang, Lingling;Wang, Jingkui;Baehr, Andrea;Petrover, Zachary;Sarig, Rachel;Dorn, Tatjana;Moretti, Alessandra;Saez-Rodriguez, Julio;Kupatt, Christian;Tanaka, Elly M;Medzhitov, Ruslan;Krüger, Achim;Mayo, Avi;Alon, Uri;Tzahor, Eldad
Cold and hot fibrosis define clinically distinct cardiac pathologies.
Cell Syst
2025
16
3

Klein, Dominik;Palla, Giovanni;Lange, Marius;Klein, Michal;Piran, Zoe;Gander, Manuel;Meng-Papaxanthos, Laetitia;Sterr, Michael;Saber, Lama;Jing, Changying;Bastidas-Ponce, Aimée;Cota, Perla;Tarquis-Medina, Marta;Parikh, Shrey;Gold, Ilan;Lickert, Heiko;Bakhti, Mostafa;Nitzan, Mor;Cuturi, Marco;Theis, Fabian J
Mapping cells through time and space with moscot.
Nature
2025
638
8052
1065-1075

Xu, Quan;Halle, Lennard;Hediyeh-Zadeh, Soroor;Kuijs, Merel;Riedweg, Rya;Kilik, Umut;Recaldin, Timothy;Yu, Qianhui;Rall, Isabell;Frum, Tristan;Adam, Lukas;Parikh, Shrey;Kfuri-Rubens, Raphael;Gander, Manuel;Klein, Dominik;Curion, Fabiola;He, Zhisong;Fleck, Jonas Simon;Oost, Koen;Kahnwald, Maurice;Barbiero, Silvia;Mitrofanova, Olga;Maciag, Grzegorz Jerzy;Jensen, Kim B;Lutolf, Matthias;Liberali, Prisca;Spence, Jason R;Gjorevski, Nikolche;Beumer, Joep;Treutlein, Barbara;Theis, Fabian J;Camp, J Gray
An integrated transcriptomic cell atlas of human endoderm-derived organoids.
Nat Genet
2025
57
5
1201-1212

Zhang, Fangfang;Dorn, Tatjana;Gnutti, Barbara;Anikster, Yair;Kuebler, Sarah;Ahrens-Nicklas, Rebecca;Gosselin, Rachel;Rahman, Shamima;Durst, Ronen;Zanuttigh, Enrica;Güra, Miriam A;Poch, Christine M;Meier, Anna B;Laugwitz, Karl-Ludwig;Schüller, Hans-Joachim;Messias, Ana C;Sibon, Ody C;Finazzi, Dario;Rippert, Alyssa;Li, Dong;Truxal, Kristen;Nandi, Deipanjan;Lampert, Brent C;Yeo, Mildrid;Gardham, Alice;Nissan, Batel;Horowitz Cederboim, Smadar;Moretti, Alessandra;Iuso, Arcangela
Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models.
Commun Med (Lond)
2025
5
1

Dorn, Tatjana;Moretti, Alessandra
European Research Council-funded grant: programming the epicardium to cure broken hearts.
Eur Heart J
2025
46
9
781-783