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Title:

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Griger, Joscha; Widholz, Sebastian A; Jesinghaus, Moritz; de Andrade Krätzig, Niklas; Lange, Sebastian; Engleitner, Thomas; Montero, Juan José; Zhigalova, Ekaterina; Öllinger, Rupert; Suresh, Veveeyan; Winkler, Wiebke; Lier, Svenja; Baranov, Olga; Trozzo, Riccardo; Ben Khaled, Najib; Chakraborty, Shounak; Yu, Jiakun; Konukiewitz, Björn; Steiger, Katja; Pfarr, Nicole; Rajput, Ashish; Sailer, David; Keller, Gisela; Schirmacher, Peter; Röcken, Christoph; Fagerstedt, Klaus W; Mayerle, Julia; Schmidt...     »
Abstract:
Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome sequencing to characterize the genomic landscapes of human G-NEC and its histologic variants. We identify global and subtype-specific alterations and expose hitherto unappreciated gains of MYC family members in a large part of cases. Genetic engineering and lineage tracing in mice delineate a model of G-NEC evolution, which defines MYC as a critic...     »
Journal title abbreviation:
Cancer Cell
Year:
2023
Journal volume:
41
Journal issue:
7
Pages contribution:
1327-1344.e10
Fulltext / DOI:
doi:10.1016/j.ccell.2023.06.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37352862
Print-ISSN:
1535-6108
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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