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Title:

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Falcomatà, Chiara; Bärthel, Stefanie; Schneider, Günter; Rad, Roland; Schmidt-Supprian, Marc; Saur, Dieter
Abstract:
UNLABELLED: Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficacy. The landscape of the TME differs substantially across PDAC subtypes, indicating context-specific principles of immunosuppression. In this review, we discuss how PDAC cells, the local TME, and systemic host and environmental factors dri...     »
Journal title abbreviation:
Cancer Discov
Year:
2023
Journal volume:
13
Journal issue:
2
Pages contribution:
278-297
Fulltext / DOI:
doi:10.1158/2159-8290.CD-22-0876
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36622087
Print-ISSN:
2159-8274
TUM Institution:
Professur für Experimentelle Hämatologie (Prof. Schmidt-Supprian); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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