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Titel:

Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Sanchez-Gonzalez, Rosario; Koupourtidou, Christina; Lepko, Tjasa; Zambusi, Alessandro; Novoselc, Klara Tereza; Durovic, Tamara; Aschenbroich, Sven; Schwarz, Veronika; Breunig, Christopher T.; Straka, Hans; Huttner, Hagen B.; Irmler, Martin; Beckers, Johannes; Wurst, Wolfgang; Zwergal, Andreas; Schauer, Tamas; Straub, Tobias; Czopka, Tim; Trümbach, Dietrich; Götz, Magdalena; Stricker, Stefan H.; Ninkovic, Jovica
Abstract:
The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain injury. However, regulatory pathways steering the OPC reaction as well as the role of reactive OPCs remain largely unknown. Here, we compared a long-lasting, exacerbated reaction of OPCs to the adult zebrafish brain injury with a timely restricted OPC activation to identify the specific molecular mechanisms regulating OPC reactivity and their contribution to regeneration. We demonstrated that the...     »
Zeitschriftentitel:
Cells
Jahr:
2022
Band / Volume:
11
Heft / Issue:
3
Volltext / DOI:
doi:10.3390/cells11030520
WWW:
https://www.mdpi.com/2073-4409/11/3/520
Print-ISSN:
2073-4409
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