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Titel:

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment.

Dokumenttyp:
Article; Journal Article
Autor(en):
Falcomatà, Chiara; Bärthel, Stefanie; Widholz, Sebastian A; Schneeweis, Christian; Montero, Juan José; Toska, Albulena; Mir, Jonas; Kaltenbacher, Thorsten; Heetmeyer, Jeannine; Swietlik, Jonathan J; Cheng, Jing-Yuan; Teodorescu, Bianca; Reichert, Oliver; Schmitt, Constantin; Grabichler, Kathrin; Coluccio, Andrea; Boniolo, Fabio; Veltkamp, Christian; Zukowska, Magdalena; Vargas, Angelica Arenas; Paik, Woo Hyun; Jesinghaus, Moritz; Steiger, Katja; Maresch, Roman; Öllinger, Rupert; Ammon, Tim; Bara...     »
Abstract:
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene dosage and subsequent high expression levels of oncogenic KRAS, shows the most aggressive phenotype and strongest therapy resistance. In the present study, we performed a systematic high-throughput combination drug screen and identified a synergistic inter...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2022
Band / Volume:
3
Heft / Issue:
3
Seitenangaben Beitrag:
318-336
Volltext / DOI:
doi:10.1038/s43018-021-00326-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35122074
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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