User: Guest  Login
Title:

Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-kappaB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells

Document type:
Zeitschriftenaufsatz
Author(s):
Mapesa, Job O.; Waldschmitt, Nadine; Schmoeller, Ingrid; Blume, Carolin; Hofmann, Thomas; Mahungu, Symon; Clavel, Thomas; Haller, Dirk
Abstract:
SCOPE: Caffeic acid phenethyl ester (CAPE) is an active constituent of honeybee propolis inhibiting nuclear factor (NF)-kappaB. The aims of our study were to provide new data on the functional relevance and mechanisms underlying the role of CAPE in regulating inflammatory processes at the epithelial interface in the gut and to determine the structure/activity relationship of CAPE. METHODS AND RESULTS: CAPE significantly inhibited TNF-induced IP-10 expression in intestinal epithelial cells. Using...     »
Journal title:
Molecular nutrition & Food research
Year:
2011
Journal volume:
55
Journal issue:
12
Pages contribution:
1850--1861
Fulltext / DOI:
doi:10.1002/mnfr.201100105
Print-ISSN:
1613-4125
 BibTeX