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Title:

Antiadhesion as a functional concept for prevention of pathogens: N-Phenylpropenoyl-L-amino acid amides as inhibitors of the Helicobacter pylori BabA outer membrane protein

Document type:
Zeitschriftenaufsatz
Author(s):
Niehues, Michael; Stark, Timo; Keller, Daniela; Hofmann, Thomas; Hensel, Andreas
Abstract:
SCOPE: Besides flavan-3-ols, a family of N-phenylpropenoyl-L-amino acids (NPAs) has been recently identified as polyphenol/amino acid conjugates in the seeds of Theobroma cacao as well as in a variety of herbal drugs. NPAs were shown to exhibit antiadhesive activities against Helicobacter pylori. METHODS AND RESULTS: For structure/activity relationship 24 homologous NPAs (2 mM) were investigated in a flow cytometric assay on potential antiadhesive effects against H. pylori adhesion to human gast...     »
Journal title:
Molecular nutrition & Food research
Year:
2011
Journal volume:
55
Journal issue:
7
Pages contribution:
1104--1117
Fulltext / DOI:
doi:10.1002/mnfr.201000548
Print-ISSN:
1613-4125
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