Benutzer: Gast  Login
Titel:

Antiadhesion as a functional concept for prevention of pathogens: N-Phenylpropenoyl-L-amino acid amides as inhibitors of the Helicobacter pylori BabA outer membrane protein

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Niehues, Michael; Stark, Timo; Keller, Daniela; Hofmann, Thomas; Hensel, Andreas
Abstract:
SCOPE: Besides flavan-3-ols, a family of N-phenylpropenoyl-L-amino acids (NPAs) has been recently identified as polyphenol/amino acid conjugates in the seeds of Theobroma cacao as well as in a variety of herbal drugs. NPAs were shown to exhibit antiadhesive activities against Helicobacter pylori. METHODS AND RESULTS: For structure/activity relationship 24 homologous NPAs (2 mM) were investigated in a flow cytometric assay on potential antiadhesive effects against H. pylori adhesion to human gast...     »
Zeitschriftentitel:
Molecular nutrition & Food research
Jahr:
2011
Band / Volume:
55
Heft / Issue:
7
Seitenangaben Beitrag:
1104--1117
Volltext / DOI:
doi:10.1002/mnfr.201000548
Print-ISSN:
1613-4125
 BibTeX