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Document type:
Journal Article; Article 
Author(s):
Seiss, M; Nitz, S; Kleinsasser, N; Buters, JT; Behrendt, H; Hickel, R; Reichl, FX 
Title:
Identification of 2,3-epoxymethacrylic acid as an intermediate in the metabolism of dental materials in human liver microsomes. 
Abstract:
OBJECTIVES: In previous studies it could be demonstrated that methacrylic acid (MA) is an intermediate in the metabolism of unpolymerized dental comonomers, released from dental restorative materials. This study was performed to identify the possible dental material intermediate 2,3-epoxymethacrylic acid (2,3-EMA) from MA in human liver microsomes. Most epoxy compounds are regarded as highly toxic substances. METHODS: The formation and hydrolysis were studied in defined systems containing only M...    »
 
Journal title abbreviation:
Dent Mater 
Year:
2007 
Journal volume:
23 
Journal issue:
Pages contribution:
9-16 
Language:
eng 
Print-ISSN:
0109-5641 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)