Dietz, Hendrik (Prof. Dr.); Simmel, Friedrich C. (Prof. Dr.)
Language:
en
Subject group:
PHY Physik
Keywords:
DNA origami, DNA nanotechnology
Translated keywords:
DNA origami, DNA Nanotechnologie
TUM classification:
PHY 820; TEC 030
Abstract:
To address the accurate structural interpretation of cryogenic electron microscopy maps of DNA nanostructures we develop semi-automated protocols for molecular dynamics-based atomic model building.
These models enable annotation and contextualization of the electron density, targeted inspection of isolated design motifs, structural comparison of design iterations, reproducible quantification of global object properties, and provide a reference for the validation of structure prediction models.
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To address the accurate structural interpretation of cryogenic electron microscopy maps of DNA nanostructures we develop semi-automated protocols for molecular dynamics-based atomic model building.
These models enable annotation and contextualization of the electron density, targeted inspection of isolated design motifs, structural comparison of design iterations, reproducible quantification of global object properties, and provide a reference for the validation of structure prediction models....
»
Translated abstract:
Um die strukturelle Interpretation von Kryo-EM Daten von DNA-Nanostrukturen zu ermöglichen, entwickeln wir Molekular-Dynamik basierte, halb-automatische Protokolle zum Bau von Atom-Modellen.
Diese Modelle erlauben die Annotation und Kontextualisierung der Elektronendichten, Inspektion isolierter Motive, den Vergleich unterschiedlicher Iterationen, reproduzierbare Quantifizierung globaler Eigenschaften, und bilden einen Referenz-Datensatz für die Validierung von Strukturvorhersage-Modellen.