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Title:

Impairments of glutamatergic synaptic transmission in Alzheimer's disease.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Zott, Benedikt; Konnerth, Arthur
Abstract:
One of the hallmarks of Alzheimer's disease (AD) is structural cell damage and neuronal death in the brains of affected individuals. As these changes are irreversible, it is important to understand their origins and precursors in order to develop treatment strategies against AD. Here, we review evidence for AD-specific impairments of glutamatergic synaptic transmission by relating evidence from human AD subjects to functional studies in animal models of AD. The emerging picture is that early in...     »
Journal title abbreviation:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Year:
2023
Journal volume:
139
Pages contribution:
24-34
Fulltext / DOI:
doi:10.1016/j.semcdb.2022.03.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35337739
Print-ISSN:
1084-9521
TUM Institution:
Professur für Neuroradiologie (Prof. Zimmer)
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