Burkart, Sandy S;Schweinoch, Darius;Frankish, Jamie;Sparn, Carola;Wüst, Sandra;Urban, Christian;Merlo, Marta;Magalhães, Vladimir G;Piras, Antonio;Pichlmair, Andreas;Willemsen, Joschka;Kaderali, Lars;Binder, Marco
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response.
Life Sci Alliance
2023
6
10

Reinke, Patrick Y A;de Souza, Edmarcia Elisa;Günther, Sebastian;Falke, Sven;Lieske, Julia;Ewert, Wiebke;Loboda, Jure;Herrmann, Alexander;Rahmani Mashhour, Aida;Karničar, Katarina;Usenik, Aleksandra;Lindič, Nataša;Sekirnik, Andreja;Botosso, Viviane Fongaro;Santelli, Gláucia Maria Machado;Kapronezai, Josana;de Araújo, Marcelo Valdemir;Silva-Pereira, Taiana Tainá;Filho, Antônio Francisco de Souza;Tavares, Mariana Silva;Flórez-Álvarez, Lizdany;de Oliveira, Danielle Bruna Leal;Durigon, Edison Luiz;Giaretta, Paula Roberta;Heinemann, Marcos Bryan;Hauser, Maurice;Seychell, Brandon;Böhler, Hendrik;Rut, Wioletta;Drag, Marcin;Beck, Tobias;Cox, Russell;Chapman, Henry N;Betzel, Christian;Brehm, Wolfgang;Hinrichs, Winfried;Ebert, Gregor;Latham, Sharissa L;Guimarães, Ana Marcia de Sá;Turk, Dusan;Wrenger, Carsten;Meents, Alke
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol
2023
6
1

Garnish, Sarah E;Martin, Katherine R;Kauppi, Maria;Jackson, Victoria E;Ambrose, Rebecca;Eng, Vik Ven;Chiou, Shene;Meng, Yanxiang;Frank, Daniel;Tovey Crutchfield, Emma C;Patel, Komal M;Jacobsen, Annette V;Atkin-Smith, Georgia K;Di Rago, Ladina;Doerflinger, Marcel;Horne, Christopher R;Hall, Cathrine;Young, Samuel N;Cook, Matthew;Athanasopoulos, Vicki;Vinuesa, Carola G;Lawlor, Kate E;Wicks, Ian P;Ebert, Gregor;Ng, Ashley P;Slade, Charlotte A;Pearson, Jaclyn S;Samson, André L;Silke, John;Murphy, James M;Hildebrand, Joanne M
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Nat Commun
2023
14
1

Li, Yao;Slavik, Kailey M;Toyoda, Hunter C;Morehouse, Benjamin R;de Oliveira Mann, Carina C;Elek, Anamaria;Levy, Shani;Wang, Zhenwei;Mears, Kepler S;Liu, Jingjing;Kashin, Dmitry;Guo, Ximing;Mass, Tali;Sebé-Pedrós, Arnau;Schwede, Frank;Kranzusch, Philip J
cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell
2023
186
15
3261-3276.e20

Li, Yao;Slavik, Kailey M;Morehouse, Benjamin R;de Oliveira Mann, Carina C;Mears, Kepler;Liu, Jingjing;Kashin, Dmitry;Schwede, Frank;Kranzusch, Philip J
cGLRs are a diverse family of pattern recognition receptors in animal innate immunity.
bioRxiv
2023

Hirschenberger, Maximilian;Lepelley, Alice;Rupp, Ulrich;Klute, Susanne;Hunszinger, Victoria;Koepke, Lennart;Merold, Veronika;Didry-Barca, Blaise;Wondany, Fanny;Bergner, Tim;Moreau, Tatiana;Rodero, Mathieu P;Rösler, Reinhild;Wiese, Sebastian;Volpi, Stefano;Gattorno, Marco;Papa, Riccardo;Lynch, Sally-Ann;Haug, Marte G;Houge, Gunnar;Wigby, Kristen M;Sprague, Jessica;Lenberg, Jerica;Read, Clarissa;Walther, Paul;Michaelis, Jens;Kirchhoff, Frank;de Oliveira Mann, Carina C;Crow, Yanick J;Sparrer, Konstantin M J
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Nat Commun
2023
14
1

Emslander, Quirin;Krey, Karsten;Hamad, Sabri;Maidl, Susanne;Oubraham, Lila;Hesse, Joshua;Henrici, Alexander;Austen, Katharina;Mergner, Julia;Grass, Vincent;Pichlmair, Andreas
MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake.
Viruses
2023
15
8

Govande, Apurva A;Babnis, Aleksandra W;Urban, Christian;Habjan, Matthias;Hartmann, Rune;Kranzusch, Philip J;Pichlmair, Andreas
RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1.
J Gen Virol
2023
104
9

Denolly, Solène;Guo, Hongbo;Martens, Miriam;Płaszczyca, Anna;Scaturro, Pietro;Prasad, Vibhu;Kongmanas, Kessiri;Punyadee, Nuntaya;Songjaeng, Adisak;Mairiang, Dumrong;Pichlmair, Andreas;Avirutnan, Panisadee;Bartenschlager, Ralf
Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin.
MBio
2023
14
5

Schmidt, Nora;Ganskih, Sabina;Wei, Yuanjie;Gabel, Alexander;Zielinski, Sebastian;Keshishian, Hasmik;Lareau, Caleb A;Zimmermann, Liv;Makroczyova, Jana;Pearce, Cadence;Krey, Karsten;Hennig, Thomas;Stegmaier, Sebastian;Moyon, Lambert;Horlacher, Marc;Werner, Simone;Aydin, Jens;Olguin-Nava, Marco;Potabattula, Ramya;Kibe, Anuja;Dölken, Lars;Smyth, Redmond P;Caliskan, Neva;Marsico, Annalisa;Krempl, Christine;Bodem, Jochen;Pichlmair, Andreas;Carr, Steven A;Chlanda, Petr;Erhard, Florian;Munschauer, Mathias
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.
Cell
2023
186
22
4834-4850.e23