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IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies.
JCI Insight
2026
11
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Borkowska, Andzelika;Juhas, Ulana;Olszewski, Szczepan;Reczkowicz, Joanna;Wityk, Pawel;Akdogan, Banu;Zischka, Hans;Antosiewicz, Jedrzej
N-homocysteinylation of ferritin and associated changes in iron metabolism as potential drivers of vascular endothelial dysfunction in hyperhomocysteinemia.
Chem Biol Interact
2026
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Engler, Jonas;Kim, Eun-Jung;Kim, Dasol;Shibata, Noreene M;Lynderup, Emilie Munk;Vendelbo, Mikkel H;Akdogan, Banu;Sailer, Judith;Fontes, Adriana;Eberhagen, Carola;Rieder, Tamara;Reinold, Quirin;Lee, Hongjae;Park, Dongsik;Jung, Chunwon;Im, Weonbin;Wudy, Susanne I;Kleigrewe, Karin;Engelhardt, Stefan;DiSpirito, Alan A;Sandahl, Thomas Damgaard;Medici, Valentina;Eun, So-Young;Zischka, Hans
Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents.
Biomed Pharmacother
2025
193

Ramasubramanian, Sankaranarayanan;Öllinger, Rupert;Eberhagen, Carola;Zischka, Hans;Schmid, Roland M;Einwächter, Henrik
Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer.
Cell Commun Signal
2025
23
1

Lorenz, Svenja M;Wahida, Adam;Bostock, Mark J;Seibt, Tobias;Santos Dias Mourão, André;Levkina, Anastasia;Trümbach, Dietrich;Soudy, Mohamed;Emler, David;Rothammer, Nicola;Woo, Marcel S;Sonner, Jana K;Novikova, Mariia;Henkelmann, Bernhard;Aldrovandi, Maceler;Kaemena, Daniel F;Mishima, Eikan;Vermonden, Perrine;Zong, Zhi;Cheng, Deng;Nakamura, Toshitaka;Ito, Junya;Doll, Sebastian;Proneth, Bettina;Bürkle, Erika;Rizzollo, Francesca;Escamilla Ayala, Abril;Napolitano, Valeria;Kolonko-Adamska, Marta;Gaussmann, Stefan;Merl-Pham, Juliane;Hauck, Stefanie;Pertek, Anna;Orschmann, Tanja;van San, Emily;Vanden Berghe, Tom;Hass, Daniela;Maida, Adriano;Frenz, Joris M;Pedrera, Lohans;Dolga, Amalia;Kraiger, Markus;Hrabé de Angelis, Martin;Fuchs, Helmut;Ebert, Gregor;Lenberg, Jerica;Friedman, Jennifer;Scale, Carolin;Agostinis, Patrizia;Zimprich, Annemarie;Vogt-Weisenhorn, Daniela;Garrett, Lillian;Hölter, Sabine M;Wurst, Wolfgang;Glaab, Enrico;Lewerenz, Jan;Popper, Bastian;Sieben, Christian;Steinacker, Petra;Zischka, Hans;Garcia-Saez, Ana J;Tietze, Anna;Ramesh, Sanath Kumar;Ayton, Scott;Vincendeau, Michelle;Friese, Manuel A;Wigby, Kristen;Sattler, Michael;Mann, Matthias;Ingold, Irina;Jayavelu, Ashok Kumar;Popowicz, Grzegorz M;Conrad, Marcus
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.
Cell
2026
189
1
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Caceres, Amanda;Shibata, Noreene M;Davalos-Gutierrez, Christian D;Sarode, Gaurav V;Hussan, Hisham;Bettencourt, Margarida;Fontes, Adriana;Zischka, Hans;Lutsenko, Svetlana;Heffern, Marie C;Medici, Valentina
Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology.
Am J Pathol
2026
196
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Lynderup, Emilie Munk;Vendelbo, Mikkel Holm;Kirk, Frederik Teicher;Vase, Karina Højrup;Alstrup, Aage Kristian Olsen;Rieder, Tamara;DiSpirito, Alan A;Semrau, Jeremy D;Laursen, Tea Lund;Ott, Peter;Zischka, Hans;Sandahl, Thomas Damgaard
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI.
Br J Pharmacol
2026
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Bremer, Juliane;Nagel, Judith;Zschüntzsch, Jana;Zajt, Kamil K;Palaz, Tayfun;Blank, Thomas;Ikis, Aylin;Fischer, Laura A;Sensmeyer, Anna S M;Wiechers, Lara;Reichelt, Josef J;Hofmann, Kai P;Wolf, Monika J;Leuchtenberger, Corinna;Tripathi, Priyanka;Einer, Claudia;Zischka, Hans;Rothermel, Ulrike;Eck, Anna-L;Reimann, Regina;Kana, Veronika;Rushing, Elisabeth;Aguzzi, Adriano;Prinz, Marco;Liebetanz, David;Odoardi, Francesca;Kuo, Chao-Chung;Weis, Joachim;Kraft, Florian;Schmidt, Jens;Heikenwälder, Mathias
Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle.
Brain
2025
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12
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Deschler, Sebastian;Pohl-Topcu, Junika;Ramsauer, Lukas;Meiser, Philippa;Erlacher, Sophia;Schenk, Robin P;Maurer, H Carlo;Shen, Peng;Kager, Juliane;Zink, Joseph;Pistrenko, Karyna;Monte, Enric Redondo;Weber, Julius;Wasmaier, Lena;Laschinger, Melanie;Hüser, Norbert;Geisler, Fabian;Thorburn, Douglas;Nieß, Hanno;Wiedemann, Gabriela M;Zischka, Hans;Heikenwälder, Mathias;Kleigrewe, Karin;Mogler, Carolin;Böttcher, Jan P;Knolle, Percy A;Schmid, Roland M;Böttcher, Katrin
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD.
J Hepatol
2025
83
6
1364-1378

Jauch, A T;Sailer, J;Braun, J;Czeslik, E;Geyer, J;Eberhagen, C;Vollmar, A M;Zischka, H;Sieber, S A;Zahler, S
Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress.
Cell Death Discov
2025
11
1