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Titel:

IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lavazais, Stéphanie; Jargosch, Manja; Dupont, Sonia; Labéguère, Frédéric; Menet, Christel; Jagerschmidt, Catherine; Ohm, Frenz; Kupcsik, Laszlo; Parent, Isabelle; Cottereaux, Céline; Marsais, Florence; Oste, Line; Van de Water, An; Christophe, Thierry; De Vos, Steve; Fallon, Padraic; Lauffer, Felix; Clément-Lacroix, Philippe; Eyerich, Kilian; Brys, Reginald
Abstract:
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated inflammatory diseases. IRAK4 is a kinase that integrates signaling downstream of receptors acting at the interface between innate and adaptive immune responses, such as Toll-like receptors (TLRs), interleukin-1R (IL-1R), and IL-18R. Because effects of IRA...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2023
Band / Volume:
15
Heft / Issue:
683
Volltext / DOI:
doi:10.1126/scitranslmed.abj3289
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36791209
Print-ISSN:
1946-6234
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann)
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