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Titel:

Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Mäntyselkä, Sakari; Kolari, Kalle; Baumert, Philipp; Ylä-Outinen, Laura; Kuikka, Lauri; Lahtonen, Suvi; Permi, Perttu; Wackerhage, Henning; Kalenius, Elina; Kivelä, Riikka; Hulmi, Juha J.
Abstract:
Cells use glycolytic intermediates for anabolism, e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes that limit protein synthesis, myotube size, and proliferation in skeletal muscle cells. We inhibited key enzymes of glycolysis, the pentose phosphate pathway, and the serine synthesis pathway to evaluate t...     »
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie
Zeitschriftentitel:
American Journal of Physiology-Endocrinology and Metabolism
Jahr:
2024
Band / Volume:
326
Jahr / Monat:
2024-01
Quartal:
1. Quartal
Monat:
Jan
Heft / Issue:
1
Seitenangaben Beitrag:
E73-E91
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1152/ajpendo.00151.2023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37991454
WWW:
https://journals.physiology.org/doi/epdf/10.1152/ajpendo.00151.2023
Verlag / Institution:
American Physiological Society
E-ISSN:
0193-18491522-1555
Impact Factor:
5,1
Scimago-Quartil:
Q1
Hinweise:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Publikationsdatum:
01.01.2024
Semester:
WS 23-24
TUM Einrichtung:
Sportbiologie
Format:
Bild/Text
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