Pedde, Anna-Marie;Kim, Hyunu;Donakonda, Sainitin;Baumann, Tobias;Bayerl, Felix;Meiser, Philippa;Hirschberger, Anna;Klement, Christine;Grassmann, Simon;Öllinger, Rupert;Hüser, Norbert;Hartmann, Daniel;Laschinger, Melanie;Trapani, Joseph A;Zippelius, Alfred;Bald, Tobias;Wiedemann, Gabriela M;Rad, Roland;Sun, Joseph C;Höchst, Bastian;Böttcher, Jan P
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.
Cell Rep
2024
43
11

Füchsl, Franziska;Untch, Johannes;Kavaka, Vladyslav;Zuleger, Gabriela;Braun, Sarah;Schwanzer, Antonia;Jarosch, Sebastian;Vogelsang, Carolin;de Andrade Krätzig, Niklas;Gosmann, Dario;Öllinger, Rupert;Giansanti, Piero;Hiltensperger, Michael;Rad, Roland;Busch, Dirk H;Beltrán, Eduardo;Bräunlein, Eva;Krackhardt, Angela M
High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells.
Nat Commun
2024
15
1

Merz, Sarah;Senée, Valérie;Philippi, Anne;Oswald, Franz;Shaigan, Mina;Führer, Marita;Drewes, Cosima;Allgöwer, Chantal;Öllinger, Rupert;Heni, Martin;Boland, Anne;Deleuze, Jean-François;Birkhofer, Franziska;Gusmao, Eduardo G;Wagner, Martin;Hohwieler, Meike;Breunig, Markus;Rad, Roland;Siebert, Reiner;Messerer, David Alexander Christian;Costa, Ivan G;Alvarez, Fernando;Julier, Cécile;Kleger, Alexander;Heller, Sandra
A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes.
Cell Rep
2024
43
11

Ringelhan, Marc;Schuehle, Svenja;van de Klundert, Maarten;Kotsiliti, Elena;Plissonnier, Marie-Laure;Faure-Dupuy, Suzanne;Riedl, Tobias;Lange, Sebastian;Wisskirchen, Karin;Thiele, Frank;Cheng, Cho-Chin;Yuan, Detian;Leone, Valentina;Schmidt, Ronny;Hünergard, Juliana;Geisler, Fabian;Unger, Kristian;Algül, Hana;Schmid, Roland M;Rad, Roland;Wedemeyer, Heiner;Levrero, Massimo;Protzer, Ulrike;Heikenwalder, Mathias
HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx.
JHEP Rep
2024
6
10

Hong, Ting;Hogger, Anna C;Wang, Dongbiao;Pan, Qi;Gansel, Julie;Engleitner, Thomas;Öllinger, Rupert;Gschwend, Jürgen E;Rad, Roland;Nawroth, Roman
CDK4/6 inhibition initiates cell cycle arrest by nuclear translocation of RB and induces a multistep molecular response.
Cell Death Discov
2024
10
1

Papargyriou, Aristeidis;Najajreh, Mulham;Cook, David P;Maurer, Carlo H;Bärthel, Stefanie;Messal, Hendrik A;Ravichandran, Sakthi K;Richter, Till;Knolle, Moritz;Metzler, Thomas;Shastri, Akul R;Öllinger, Rupert;Jasper, Jacob;Schmidleitner, Laura;Wang, Surui;Schneeweis, Christian;Ishikawa-Ankerhold, Hellen;Engleitner, Thomas;Mataite, Laura;Semina, Mariia;Trabulssi, Hussein;Lange, Sebastian;Ravichandra, Aashreya;Schuster, Maximilian;Mueller, Sebastian;Peschke, Katja;Schäfer, Arlett;Dobiasch, Sophie;Combs, Stephanie E;Schmid, Roland M;Bausch, Andreas R;Braren, Rickmer;Heid, Irina;Scheel, Christina H;Schneider, Günter;Zeigerer, Anja;Luecken, Malte D;Steiger, Katja;Kaissis, Georgios;van Rheenen, Jacco;Theis, Fabian J;Saur, Dieter;Rad, Roland;Reichert, Maximilian
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
Nat Biomed Eng
2024

Sperk, Anna;Gabriel, Antje;Koch, Daniela;Augsburger, Abirami;Sanchez, Victoria;Brockelt, David;Öllinger, Rupert;Engleitner, Thomas;Giansanti, Piero;Ludwig, Romina;Auf der Maur, Priska;Walter, Wencke;Haferlach, Torsten;Jeremias, Irmela;Rad, Roland;Steigenberger, Barbara;Kuster, Bernhard;Eichner, Ruth;Bassermann, Florian
FBXL6 is a vulnerability in AML and unmasks proteolytic cleavage as a major experimental pitfall in myeloid cells.
Leukemia
2024
38
9
2027-2031

Tretter, Celina;Kraetzig, Niklas de Andrade;Pecoraro, Matteo;Lange, Sebastian;Seifert, Philipp;von Frankenberg, Clara;Untch, Johannes;Zuleger, Gabriela;Wilhelm, Mathias;Zolg, Daniel P.;Dreyer, Florian S.;Braeunlein, Eva;Engleitner, Thomas;Uhrig, Sebastian;Boxberg, Melanie;Steiger, Katja;Slotta-Huspenina, Julia;Ochsenreither, Sebastian;von Bubnoff, Nikolas;Bauer, Sebastian;Boerries, Melanie;Jost, Philipp J.;Schenck, Kristina;Dresing, Iska;Bassermann, Florian;Friess, Helmut;Reim, Daniel;Gruetzmann, Konrad;Pfuetze, Katrin;Klink, Barbara;Schroeck, Evelin;Haller, Bernhard;Kuster, Bernhard;Mann, Matthias;Weichert, Wilko;Froehling, Stefan;Rad, Roland;Hiltensperger, Michael;Krackhardt, Angela M.
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification (vol 14, 4632, 2023)
Nat Commun
2024
15
1

Lier, Svenja;Sellmer, Andreas;Orben, Felix;Heinzlmeir, Stephanie;Krauß, Lukas;Schneeweis, Christian;Hassan, Zonera;Schneider, Carolin;Schäfer, Arlette;Pongratz, Herwig;Engleitner, Thomas;Öllinger, Rupert;Kuisl, Anna;Bassermann, Florian;Schlag, Christoph;Kong, Bo;Dove, Stefan;Kuster, Bernhard;Rad, Roland;Reichert, Maximilian;Wirth, Matthias;Saur, Dieter;Mahboobi, Siavosh;Schneider, Günter
Corrigendum to "A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer" [Bioorgan. Chem. 119 (2022) 105505].
Bioorg Chem
2024
146

Maione, Federica;Oddo, Daniele;Galvagno, Federica;Falcomatà, Chiara;Pandini, Marta;Macagno, Marco;Pessei, Valeria;Barault, Ludovic;Gigliotti, Chiara;Mira, Alessia;Corti, Giorgio;Lamba, Simona;Riganti, Chiara;Castella, Barbara;Massaia, Massimo;Rad, Roland;Saur, Dieter;Bardelli, Alberto;Di Nicolantonio, Federica
Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models.
Mol Oncol
2024
18
6
1552-1570