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Title:

Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling

Document type:
Zeitschriftenaufsatz
Author(s):
Mäntyselkä, Sakari; Kolari, Kalle; Baumert, Philipp; Ylä-Outinen, Laura; Kuikka, Lauri; Lahtonen, Suvi; Permi, Perttu; Wackerhage, Henning; Kalenius, Elina; Kivelä, Riikka; Hulmi, Juha J.
Abstract:
Cells use glycolytic intermediates for anabolism, e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes that limit protein synthesis, myotube size, and proliferation in skeletal muscle cells. We inhibited key enzymes of glycolysis, the pentose phosphate pathway, and the serine synthesis pathway to evaluate t...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie
Journal title:
American Journal of Physiology-Endocrinology and Metabolism
Year:
2024
Journal volume:
326
Year / month:
2024-01
Quarter:
1. Quartal
Month:
Jan
Journal issue:
1
Pages contribution:
E73-E91
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1152/ajpendo.00151.2023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37991454
WWW:
https://journals.physiology.org/doi/epdf/10.1152/ajpendo.00151.2023
Publisher:
American Physiological Society
E-ISSN:
0193-18491522-1555
Impact Factor:
5,1
Scimago Quartil:
Q1
Notes:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Date of publication:
01.01.2024
Semester:
WS 23-24
TUM Institution:
Sportbiologie
Format:
Bild/Text
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