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Titel:

Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs.

Dokumenttyp:
Journal Article
Autor(en):
Baeten, Paulien; Hamad, Ibrahim; Hoeks, Cindy; Hiltensperger, Michael; Van Wijmeersch, Bart; Popescu, Veronica; Aly, Lilian; Somers, Veerle; Korn, Thomas; Kleinewietfeld, Markus; Hellings, Niels; Broux, Bieke
Abstract:
In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune response. This largely affects the success of autologous Treg therapy, which is currently under investigation for autoimmune diseases, including multiple sclerosis (MS). There is a need to ensure in vivo Treg stability before successful application of Treg therapy. Using genetic fate-mapping mice, we demonstrate that inflammatory, cytokine-express...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2024
Band / Volume:
9
Heft / Issue:
7
Volltext / DOI:
doi:10.1172/jci.insight.167457
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38386413
Print-ISSN:
2379-3708
TUM Einrichtung:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle)
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