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Titel:

Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Balakrishnan, Rohan; Mori, Matteo; Segota, Igor; Zhang, Zhongge; Aebersold, Ruedi; Ludwig, Christina; Hwa, Terence
Abstract:
Protein concentrations are set by a complex interplay between gene-specific regulatory processes and systemic factors, including cell volume and shared gene expression machineries. Elucidating this interplay is crucial for discerning and designing gene regulatory systems. We quantitatively characterized gene-specific and systemic factors that affect transcription and translation genome-wide for Escherichia coli across many conditions. The results revealed two design principles that make regulati...     »
Stichworte:
BayBioMS; Bacteria - genetics; DNA; Gene Expression Regulation; RNA
Zeitschriftentitel:
Science
Jahr:
2022
Band / Volume:
378
Heft / Issue:
6624
Volltext / DOI:
doi:10.1126/science.abk2066
Verlag / Institution:
American Association for the Advancement of Science (AAAS)
E-ISSN:
0036-80751095-9203
Publikationsdatum:
09.12.2022
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