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Titel:

Spotlight on alternative frame coding: Two long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Kreitmeier, Michaela; Ardern, Zachary; Abele, Miriam; Ludwig, Christina; Scherer, Siegfried; Neuhaus, Klaus
Abstract:
The existence of overlapping genes (OLGs) with significant coding overlaps revolutionizes our understanding of genomic complexity. We report two exceptionally long (957 nt and 1536 nt), evolutionarily novel, translated antisense open reading frames (ORFs) embedded within annotated genes in the pathogenic Gram-negative bacterium Pseudomonas aeruginosa. Both OLG pairs show sequence features consistent with being genes and transcriptional signals in RNA sequencing. Translation of both OLGs was conf...     »
Stichworte:
BayBioMS; Genomic analysis; Microbiology
Zeitschriftentitel:
iScience
Jahr:
2022
Band / Volume:
25
Heft / Issue:
2
Seitenangaben Beitrag:
103844
Volltext / DOI:
doi:10.1016/j.isci.2022.103844
Verlag / Institution:
Elsevier BV
E-ISSN:
2589-0042
Publikationsdatum:
01.02.2022
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