User: Guest  Login
Title:

Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria

Document type:
Zeitschriftenaufsatz
Author(s):
Balakrishnan, Rohan; Mori, Matteo; Segota, Igor; Zhang, Zhongge; Aebersold, Ruedi; Ludwig, Christina; Hwa, Terence
Abstract:
Protein concentrations are set by a complex interplay between gene-specific regulatory processes and systemic factors, including cell volume and shared gene expression machineries. Elucidating this interplay is crucial for discerning and designing gene regulatory systems. We quantitatively characterized gene-specific and systemic factors that affect transcription and translation genome-wide for Escherichia coli across many conditions. The results revealed two design principles that make regulati...     »
Keywords:
BayBioMS; Bacteria - genetics; DNA; Gene Expression Regulation; RNA
Journal title:
Science
Year:
2022
Journal volume:
378
Journal issue:
6624
Fulltext / DOI:
doi:10.1126/science.abk2066
Publisher:
American Association for the Advancement of Science (AAAS)
E-ISSN:
0036-80751095-9203
Date of publication:
09.12.2022
 BibTeX