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Titel:

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Stepan, Jens; Heinz, Daniel E.; Dethloff, Frederik; Bajaj, Thomas; Zellner, Andreas; Hafner, Kathrin; Wiechmann, Svenja; Mackert, Sarah; Mecdad, Yara; Rabenstein, Michael; Ebert, Tim; Martinelli, Silvia; Häusl, Alexander S.; Pöhlmann, Maximilian L.; Hermann, Anke; Ma, Xiao; Pavenstädt, Hermann; Schmidt, Mathias V.; Philipsen, Alexandra; Turck, Chris W.; Deussing, Jan M.; Kuster, Bernhard; Wehr, Michael C.; Stein, Valentin; Kremerskothen, Joachim; Wotjak, Carsten T.; Gassen, Nils C.
Abstract:
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing protein 1 (WWC1) regulates AMPAR surface expression and impacts on memory performance. However, synaptic binding partners of WWC1 and its hierarchical position in AMPAR complexes are largely unclear. Using cell-surface proteomics in hippocampal tissue of...     »
Stichworte:
BayBioMS; AMPA receptor; CP: Neuroscience; Hippo pathway; KIBRA; LATS; WWC1; hippocampus; learning and memory; pro-cognitive; synapse; synaptic proteomics.
Zeitschriftentitel:
Cell Reports
Jahr:
2022
Band / Volume:
41
Heft / Issue:
10
Seitenangaben Beitrag:
111766
Volltext / DOI:
doi:10.1016/j.celrep.2022.111766
Verlag / Institution:
Elsevier BV
E-ISSN:
2211-1247
Publikationsdatum:
01.12.2022
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