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Titel:

Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Haange, Sven-Bastiaan; Till, Andreas; Bergh, Per-Olof; Fauler, Günter; Gigl, Michael; Löfgren-Sandblom, Anita; Schaap, Frank G.; Clavel, Thomas; Trautwein, Christian; Fenske, Wiebke; Kleigrewe, Karin; Marschall, Hanns-Ulrich; Olde Damink, Steven W. M.; Moustafa, Tarek; von Bergen, Martin; Rolle-Kampczyk, Ulrike
Abstract:
(1) Background: Bile acids are a key mediator of the molecular microbiome-host interaction, and various mass spectrometry-based assays have been developed in the recent decade to quantify a wide range of bile acids. We compare existing methodologies to harmonize them. (2) Methods: Methodology for absolute quantification of bile acids from six laboratories in Europe were compared for the quantification of the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) and conjugated prod...     »
Stichworte:
BayBioMS; bile acids; ring trial; LC-MS/MS; absolute quantification; human serum; murine serum
Zeitschriftentitel:
Metabolites
Jahr:
2022
Band / Volume:
12
Heft / Issue:
7
Seitenangaben Beitrag:
583
Volltext / DOI:
doi:10.3390/metabo12070583
Verlag / Institution:
MDPI AG
E-ISSN:
2218-1989
Publikationsdatum:
23.06.2022
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