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Title:

Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility

Document type:
Zeitschriftenaufsatz
Author(s):
Haange, Sven-Bastiaan; Till, Andreas; Bergh, Per-Olof; Fauler, Günter; Gigl, Michael; Löfgren-Sandblom, Anita; Schaap, Frank G.; Clavel, Thomas; Trautwein, Christian; Fenske, Wiebke; Kleigrewe, Karin; Marschall, Hanns-Ulrich; Olde Damink, Steven W. M.; Moustafa, Tarek; von Bergen, Martin; Rolle-Kampczyk, Ulrike
Abstract:
(1) Background: Bile acids are a key mediator of the molecular microbiome-host interaction, and various mass spectrometry-based assays have been developed in the recent decade to quantify a wide range of bile acids. We compare existing methodologies to harmonize them. (2) Methods: Methodology for absolute quantification of bile acids from six laboratories in Europe were compared for the quantification of the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) and conjugated prod...     »
Keywords:
BayBioMS; bile acids; ring trial; LC-MS/MS; absolute quantification; human serum; murine serum
Journal title:
Metabolites
Year:
2022
Journal volume:
12
Journal issue:
7
Pages contribution:
583
Fulltext / DOI:
doi:10.3390/metabo12070583
Publisher:
MDPI AG
E-ISSN:
2218-1989
Date of publication:
23.06.2022
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