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Title:

Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids

Document type:
Article
Author(s):
Randriamanantsoa, S.; Papargyriou, A.; Maurer, H. C.; Peschke, K.; Schuster, M.; Zecchin, G.; Steiger, K.; Oellinger, R.; Saur, D.; Scheel, C.; Rad, R.; Hannezo, E.; Reichert, M.; Bausch, A. R.
Abstract:
The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous tissues. Using single primary murine pancreatic ductal adenocarcinoma (PDAC) cells embedded in a collagen matrix and adapted media supplementation, we generate organoids that self-organize into highly branched structures displaying a seamless lumen connecting terminal end buds, replicating in...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-022-32806-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36064947
Print-ISSN:
2041-1723
TUM Institution:
1205; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie; Lehrstuhl für Translationale Tumorforschung (DKTK) (Prof. Saur); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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