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Title:

Neuronal activation by mucosal biopsy supernatants from irritable bowel syndrome patients is linked to visceral sensitivity.

Document type:
Zeitschriftenaufsatz
Author(s):
Buhner, Sabine; Braak, Breg; Li, Qin; Kugler, Eva Maria; Klooker, Tamira; Wouters, Mira; Donovan, Jemma; Vignali, Sheila; Mazzuoli-Weber, Gemma; Grundy, David; Boeckxstaens, Guy; Schemann, Michael
Abstract:
Based on the discomfort/pain threshold during rectal distension, irritable bowel syndrome (IBS) patients may be subtyped as normo- or hypersensitive. We previously showed that mucosal biopsy supernatants from IBS patients activated enteric and visceral afferent neurons. We tested the hypothesis that visceral sensitivity is linked to the degree of neuronal activation. Normo- and hypersensitive IBS patients were distinguished by their discomfort/pain threshold to rectal balloon distension with a...     »
Keywords:
Animals, Humans, Mice, Guinea Pigs, Adult, Female, Male, Middle Aged, Biopsy, Calcium Signaling/physiology, Enteric Nervous System/physiopathology, Pain Threshold, Young Adult, Ganglia, Spinal/physiopathology, Intestinal Mucosa/metabolism/pathology/*physiopathology, Irritable Bowel Syndrome/metabolism/pathology/*physiopathology, Neurons/pathology/*physiology
Journal title:
Experimental physiology
Year:
2014
Journal volume:
99
Month:
oct
Journal issue:
10
Pages contribution:
1299--1311
Language:
eng
Fulltext / DOI:
doi:10.1113/expphysiol.2014.080036
Print-ISSN:
1469-445X 0958-0670
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