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Title:

Sensitivity testing in irritable bowel syndrome with rectal capsaicin stimulations: role of {TRPV}1 upregulation and sensitization in visceral hypersensitivity?

Document type:
Zeitschriftenaufsatz
Author(s):
van Wanrooij, Sander J. M.; Wouters, Mira M.; Van Oudenhove, Lukas; Vanbrabant, Winde; Mondelaers, Stephanie; Kollmann, Patrick; Kreutz, Florian; Schemann, Michael; Boeckxstaens, Guy E.
Abstract:
OBJECTIVES: Abnormal pain perception or visceral hypersensitivity (VH) is considered to be an important mechanism underlying symptoms in a subgroup of irritable bowel syndrome (IBS) patients. Increased TRPV1 (transient receptor potential cation channel subfamily V member 1) expression in rectal biopsies of IBS patients suggests a potentially important role for this nociceptor in the pathophysiology of IBS. However, evidence underscoring the involvement of TRPV1 in visceral perception in IBS is l...     »
Keywords:
Humans, Adult, Female, Male, Biopsy, *Capsaicin, *Irritable Bowel Syndrome/genetics/pathology/physiopathology/psychology, *Rectum/innervation/pathology, *TRPV Cation Channels/agonists/genetics, Abdominal Pain/diagnosis/etiology, Anxiety/etiology, Gene Expression Profiling, Nociception/physiology, Nociceptors/metabolism, Pain Measurement, Pain Threshold/physiology/psychology, Sensory System Agents, Up-Regulation
Journal title:
The American journal of gastroenterology
Year:
2014
Journal volume:
109
Month:
jan
Journal issue:
1
Pages contribution:
99--109
Language:
eng
Fulltext / DOI:
doi:10.1038/ajg.2013.371
Print-ISSN:
1572-0241 0002-9270
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