A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase C&gamma;2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.

Title:: A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ 2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Document type:: Zeitschriftenaufsatz
Author(s):: Abe, K. ; Fuchs, H. ; Boersma, A. ; Hans, W. ; Yu, P. ; Kalaydjiev, S. ; Klaften, M. ; Adler, T. ; Calzada-Wack, J.C. ; Mossbrugger, I. ; Rathkolb, B. ; Rozman, J. ; Prehn, C. ; Maraslioglu, M. ; Kametani, Y. ; Shimada, S. ; Adamski, J. ; Busch, D.H. ; Esposito, I. ; Klingenspor, M. ; Wolf, E. ; Wurst, W. ; Gailus-Durner, V. ; Katan, M. ; Marschall, S. ; Soewarto, D. ; Wagner, S. ; Hrabé de Angelis, M.
Keywords:: Genetics and Epidemiology ; Enabling and Novel Technologies
Journal title:: Arthritis Rheum.
Year:: 2011
Journal volume:: 63
Pages contribution:: 1301-1311
Fulltext / DOI:: doi:10.1002/art.30280
E-ISSN:: 0004-3591
Impact Factor:: 8,435
Notes:: Research Programmes: Genes and Environment in Common Diseases
TUM Institution:: Institute of Experimental Genetics (IEG) ; Institute of Developmental Genetics (IDG) ; Institute of Pathology (PATH)
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A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase C&gamma; 2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.