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Title:

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Document type:
Journal Article; Article
Author(s):
Yuan, Detian; Huang, Shan; Berger, Emanuel; Liu, Lei; Gross, Nina; Heinzmann, Florian; Ringelhan, Marc; Connor, Tracy O; Stadler, Mira; Meister, Michael; Weber, Julia; Öllinger, Rupert; Simonavicius, Nicole; Reisinger, Florian; Hartmann, Daniel; Meyer, Rüdiger; Reich, Maria; Seehawer, Marco; Leone, Valentina; Höchst, Bastian; Wohlleber, Dirk; Jörs, Simone; Prinz, Marco; Spalding, Duncan; Protzer, Ulrike; Luedde, Tom; Terracciano, Luigi; Matter, Matthias; Longerich, Thomas; Knolle, Percy; Ried, T...     »
Abstract:
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells caused JNK-mediated cholangiocellular proliferation and oncogenic transformation. Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or J...     »
Journal title abbreviation:
Cancer Cell
Year:
2017
Journal volume:
31
Journal issue:
6
Pages contribution:
771-789.e6
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ccell.2017.05.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28609656
Print-ISSN:
1535-6108
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie ; Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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