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Title:

Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma

Document type:
Article
Author(s):
Dieter, SM; Heining, C; Agaimy, A; Huebschmann, D; Bonekamp, D; Hutter, B; Ehrenberg, KR; Frohlich, M; Schlesner, M; Scholl, C; Schlemmer, HP; Wolf, S; Mavratzas, A; Jung, CS; Groschel, S; von Kalle, C; Eils, R; Brors, B; Penzel, R; Kriegsmann, M; Reuss, DE; Schirmacher, P; Stenzinger, A; Federspil, PA; Weichert, W; Glimm, H; Frohling, S
Abstract:
Background: Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet share an overall poor prognosis owing to an aggressive clinical course and frequent late-stage diagnosis. The lack of effective systemic therapies for locally advanced or metastatic SNC poses a major challenge to therapeutic decision making for individual patients. We here aimed to identify actionable genetic alterations in a...     »
Journal title abbreviation:
Ann Oncol
Year:
2017
Journal volume:
28
Journal issue:
1
Pages contribution:
142-148
Language:
eng
Fulltext / DOI:
doi:10.1093/annonc/mdw446
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27687311
Print-ISSN:
0923-7534
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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