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Titel:

Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma

Dokumenttyp:
Article
Autor(en):
Dieter, SM; Heining, C; Agaimy, A; Huebschmann, D; Bonekamp, D; Hutter, B; Ehrenberg, KR; Frohlich, M; Schlesner, M; Scholl, C; Schlemmer, HP; Wolf, S; Mavratzas, A; Jung, CS; Groschel, S; von Kalle, C; Eils, R; Brors, B; Penzel, R; Kriegsmann, M; Reuss, DE; Schirmacher, P; Stenzinger, A; Federspil, PA; Weichert, W; Glimm, H; Frohling, S
Abstract:
Background: Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet share an overall poor prognosis owing to an aggressive clinical course and frequent late-stage diagnosis. The lack of effective systemic therapies for locally advanced or metastatic SNC poses a major challenge to therapeutic decision making for individual patients. We here aimed to identify actionable genetic alterations in a...     »
Zeitschriftentitel:
Ann Oncol
Jahr:
2017
Band / Volume:
28
Heft / Issue:
1
Seitenangaben Beitrag:
142-148
Sprache:
eng
Volltext / DOI:
doi:10.1093/annonc/mdw446
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27687311
Print-ISSN:
0923-7534
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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