Rhenium-Carben-Komplexe und ihre Anwendungen

Hille, Claudia Heidi

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Claudia Heidi Hille

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Original title:: Rhenium-Carben-Komplexe und ihre Anwendungen
Translated title:: Rhenium carbene complexes and their applications
Author:: Hille, Claudia Heidi
Year:: 2016
Document type:: Dissertation
Faculty/School:: Fakultät für Chemie
Advisor:: Herrmann, Wolfgang A. (Prof. Dr. Dr. h.c. mult.); Kühn, Fritz E. (Prof. Dr.)
Referee:: Herrmann, Wolfgang A. (Prof. Dr. Dr. h.c. mult.); Mink, János (Prof. Dr. Dr. h.c.)
Language:: de
Subject group:: CHE Chemie
Translated keywords:: Rhenium, NHC, Radiopharmazeutika, Carbene,
TUM classification:: CHE 330d
Abstract:: Ausgehend von Rhenium(I/V)-Vorstufen werden verschiedene Synthesewege zu wasserlöslichen und zugleich stabilen Rheniumkomplexen auf Basis von N-Heterozyklischen Carbenen (NHCs) zur Verwendung als potentielle Radiopharmaka vorgestellt sowie die Anwendbarkeit literaturbekannter Re-NHC-Komplexe diesbezüglich untersucht. Der unter Standardbedingungen synthetisierte Komplex Dioxo-bis-(1,1`-methylen-bis(3,3`-diisopropyl-imidazolium-2-yliden))rhenium(V)-hexafluorophosphat bildete die Basis des ersten radioaktiv markierten ¹⁸⁸Re(V)-NHC-Komplexes.
Translated abstract:: Based on rhenium(I/V) precursors several synthetic pathways to water soluble but at the same time stable rhenium complexes ligated with N-heterocyclic carbenes (NHCs) suitable for radiopharmaceutical application are presented and the evaluation of literature known Re NHC complexes is conducted. Dioxo-bis-(1,1`-methylene-bis(3,3`-diisopropylimidazolium-2-ylidene))rhenium(V)-hexafluorophosphate was synthesized under standard conditions providing the basis for the first radiolabeled ¹⁸⁸Re(V) NHC complex. «
Based on rhenium(I/V) precursors several synthetic pathways to water soluble but at the same time stable rhenium complexes ligated with N-heterocyclic carbenes (NHCs) suitable for radiopharmaceutical application are presented and the evaluation of literature known Re NHC complexes is conducted. Dioxo-bis-(1,1`-methylene-bis(3,3`-diisopropylimidazolium-2-ylidene))rhenium(V)-hexafluorophosphate was synthesized under standard conditions providing the basis for the first radiolabeled ¹⁸⁸Re(V) NHC co... »
WWW:: https://mediatum.ub.tum.de/?id=1286679
Date of submission:: 23.12.2015
Oral examination:: 01.02.2016
File size:: 3225431 bytes
Pages:: 175
Urn (citeable URL):: https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20160201-1286679-1-5
Last change:: 10.02.2016
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