We analyzed the familial status, clinico-pathological and follow-up records from 8138 patients after radical prostatectomy (RP) in regard to positive lymph nodes (pN0 vs. pN1).
10% showed a pN1-status. This affected significantly the 10-year PSA progression-free survival rates (PFS) (pN0: 50%; pN1: 31%). Lymph node positive patients had better 10-year PFS rates with adjuvant hormonal therapy (AHT) than without AHT (45% vs. 18%). Contrary to the pN0 group, no important impact of tumor stage on biochemical recurrence after 10 years could be identified (≤pT2: 30%; >pT3: 31%). Furthermore, familial status had no affect on long-term outcome in both groups.
Lymph node status and AHT have a strong prognostic impact after RP, in contrast to the familial status.
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We analyzed the familial status, clinico-pathological and follow-up records from 8138 patients after radical prostatectomy (RP) in regard to positive lymph nodes (pN0 vs. pN1).
10% showed a pN1-status. This affected significantly the 10-year PSA progression-free survival rates (PFS) (pN0: 50%; pN1: 31%). Lymph node positive patients had better 10-year PFS rates with adjuvant hormonal therapy (AHT) than without AHT (45% vs. 18%). Contrary to the pN0 group, no important impact of tumor stage on...
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