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Titel:

cGMP-dependent protein kinase II and aldosterone secretion.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Spiessberger, B; Bernhard, D; Herrmann, S; Feil, S; Werner, C; Luppa, PB; Hofmann, F
Abstract:
ACTH-stimulated aldosterone secretion can be inhibited by atrio-natriuretic peptide/cGMP. The mechanism behind this modulation has been reported to involve cGMP-dependent activation of phosphodiesterase 2 (PDE2) and hydrolysis of cAMP. Recently it was reported that activation of cGMP-dependent protein kinase II (cGKII) stimulated aldosterone secretion in rat zona glomerulosa cells. The zona glomerulosa of the murine adrenal cortex expresses cGKII and PDE2. We used mice with a homozygous inactiva...     »
Zeitschriftentitel:
FEBS J
Jahr:
2009
Band / Volume:
276
Heft / Issue:
4
Seitenangaben Beitrag:
1007-13
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1742-4658.2008.06839.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19154345
Print-ISSN:
1742-464X
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Institut für Pharmakologie und Toxikologie
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