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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Comparative Study; Article
Author(s):
Schmidtko, A; Gao, W; Sausbier, M; Rauhmeier, I; Sausbier, U; Niederberger, E; Scholich, K; Huber, A; Neuhuber, W; Allescher, HD; Hofmann, F; Tegeder, I; Ruth, P; Geisslinger, G
Title:
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.
Abstract:
The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been identified to date. Using a yeast two-hybrid screen, we isolated cysteine-rich protein 2 (CRP2) as a novel cGKI interactor in the spinal cord. CRP2 is expressed in laminas I and II of the mouse spinal cord and is colocalized with cGKI, calcitonin gene-related peptide, and isolectin B4. Moreover, the majority...     »
Journal title abbreviation:
J Neurosci
Year:
2008
Journal volume:
28
Journal issue:
6
Pages contribution:
1320-30
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.5037-07.2008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18256252
Print-ISSN:
0270-6474
TUM Institution:
Institut für Pharmakologie und Toxikologie
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