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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Lemke, T; Welling, A; Christel, CJ; Blaich, A; Bernhard, D; Lenhardt, P; Hofmann, F; Moosmang, S 
Title:
Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. 
Abstract:
Phosphorylation of serine 1928 (Ser(1928)) of the cardiac Ca(v)1.2 subunit of L-type Ca(2+) channels has been proposed as the mechanism for regulation of L-type Ca(2+) channels by protein kinase A (PKA). To test this directly in vivo, we generated a knock-in mouse with targeted mutation of Ser(1928) to alanine. This mutation did not affect basal L-type current characteristics or regulation of the L-type current by PKA and the beta-adrenergic receptor, whereas the mutation abolished phosphorylati...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2008 
Journal volume:
283 
Journal issue:
50 
Pages contribution:
34738-44 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie