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- Title:
Bone morphogenetic protein 7 (BMP7) expression is a potential novel prognostic marker for recurrence in patients with primary melanoma.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Rothhammer, T; Wild, PJ; Meyer, S; Bataille, F; Pauer, A; Klinkhammer-Schalke, M; Hein, R; Hofstaedter, F; Bosserhoff, AK
- Abstract:
- The purpose of this study was to investigate whether protein expression of bone morphogenetic protein 7 (BMP7) is associated with clinico-pathologic characteristics in benign and malignant melanocytic skin tumors. Tissue microarrays (TMAs) were used to analyze BMP7 expression and the Ki-67 labeling index immunohistochemically. Expression was scored semi quantitatively (0-2+). BMP7 protein expression of any intensity (1+-2+) was detected in 50.2% (153/305) of informative cases. In general, BMP7 expression was significantly induced in malignant melanomas (P< 0.001) and melanoma metastases (P< 0.001), compared to benign nevi. Additionally, expression of BMP7 in primary melanomas was associated with Ki-67 labeling index > 5% suggesting that induction of BMP7 expression is associated with proliferation (P=0.028). None of the other clinical and histological factors analyzed was significantly related to BMP7 expression. Interestingly, lymph node metastases demonstrated a significantly higher BMP7 expression compared to skin metastases (P<0.01). Strong BMP7 expression (score 2+) was significantly associated with shorter tumor recurrence (P< 0.05). In summary, induction of BMP7 expression is frequent in melanomas and may serve as a novel prognostic marker of progression in melanoma patients.
- Journal title abbreviation:
- Cancer Biomark
- Year:
- 2007
- Journal volume:
- 3
- Journal issue:
- 2
- Pages contribution:
- 111-7
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/17522432
- Print-ISSN:
- 1574-0153
- TUM Institution:
- Klinik und Poliklinik für Dermatologie und Allergologie
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