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Title:

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.

Document type:
Journal Article
Author(s):
Tsvilovskyy, Volodymyr; Ottenheijm, Roger; Kriebs, Ulrich; Schütz, Aline; Diakopoulos, Kalliope Nina; Jha, Archana; Bildl, Wolfgang; Wirth, Angela; Böck, Julia; Jaślan, Dawid; Ferro, Irene; Taberner, Francisco J; Kalinina, Olga; Hildebrand, Staffan; Wissenbach, Ulrich; Weissgerber, Petra; Vogt, Dominik; Eberhagen, Carola; Mannebach, Stefanie; Berlin, Michael; Kuryshev, Vladimir; Schumacher, Dagmar; Philippaert, Koenraad; Camacho-Londoño, Juan E; Mathar, Ilka; Dieterich, Christoph; Klugbauer, Nor...     »
Abstract:
Regulated exocytosis is initiated by increased Ca2+ concentrations in close spatial proximity to secretory granules, which is effectively prevented when the cell is at rest. Here we showed that exocytosis of zymogen granules in acinar cells was driven by Ca2+ directly released from acidic Ca2+ stores including secretory granules through NAADP-activated two-pore channels (TPCs). We identified OCaR1 (encoded by Tmem63a) as an organellar Ca2+ regulator protein integral to the membrane of secretory...     »
Journal title abbreviation:
J Clin Invest
Year:
2024
Journal volume:
134
Journal issue:
7
Fulltext / DOI:
doi:10.1172/JCI169428
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38557489
Print-ISSN:
0021-9738
TUM Institution:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher); Lehrstuhl für Tumormetabolismus (Prof. Algül)
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