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Titel:

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Dokumenttyp:
Journal Article; Article
Autor(en):
Fischer, Julius C; Otten, Vera; Steiger, Katja; Schmickl, Martina; Slotta-Huspenina, Julia; Beyaert, Rudi; van Loo, Geert; Peschel, Christian; Poeck, Hendrik; Haas, Tobias; Spoerl, Silvia
Abstract:
The NF-?B regulator A20 limits inflammation by providing negative feedback in myeloid cells and B cells. Functional lack of A20 has been linked to several inflammatory and autoimmune diseases. To define how A20 affects the functionality of T effector cells in a highly inflammatory environment, we performed conventional allogeneic hematopoietic stem cell transplantation (allo-HSCT) with A20-deficient CD4+ and CD8+ donor T cells in mice. Severity and mortality of graft-versus-host disease (GVHD) a...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2017
Band / Volume:
47
Heft / Issue:
11
Seitenangaben Beitrag:
1982-1988
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201646911
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28833031
Print-ISSN:
0014-2980
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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