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Document type:
Journal Article; Article 
Author(s):
Fischer, Julius C; Otten, Vera; Steiger, Katja; Schmickl, Martina; Slotta-Huspenina, Julia; Beyaert, Rudi; van Loo, Geert; Peschel, Christian; Poeck, Hendrik; Haas, Tobias; Spoerl, Silvia 
Title:
A20 deletion in T cells modulates acute graft-versus-host disease in mice. 
Abstract:
The NF-?B regulator A20 limits inflammation by providing negative feedback in myeloid cells and B cells. Functional lack of A20 has been linked to several inflammatory and autoimmune diseases. To define how A20 affects the functionality of T effector cells in a highly inflammatory environment, we performed conventional allogeneic hematopoietic stem cell transplantation (allo-HSCT) with A20-deficient CD4+ and CD8+ donor T cells in mice. Severity and mortality of graft-versus-host disease (GVHD) a...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2017 
Journal volume:
47 
Journal issue:
11 
Pages contribution:
1982-1988 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0014-2980 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie