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Title:

Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection.

Document type:
Journal Article
Author(s):
Albers, Julian J; Ammon, Tim; Gosmann, Dario; Audehm, Stefan; Thoene, Silvia; Winter, Christof; Secci, Ramona; Wolf, Anja; Stelzl, Anja; Steiger, Katja; Ruland, Jürgen; Bassermann, Florian; Kupatt, Christian; Anton, Martina; Krackhardt, Angela M
Abstract:
Adoptive transfer of TCR transgenic T cells holds great promise for treating various cancers. So far, mainly semi-randomly integrating vectors have been used to genetically modify T cells. These carry the risk of insertional mutagenesis, and the sole addition of an exogenous TCR potentially results in the mispairing of TCR chains with endogenous ones. Established approaches using nonviral vectors, such as transposons, already reduce the risk of insertional mutagenesis but have not accomplished s...     »
Journal title abbreviation:
Life Sci Alliance
Year:
2019
Journal volume:
2
Journal issue:
2
Language:
eng
Fulltext / DOI:
doi:10.26508/lsa.201900367
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30877233
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); I. Medizinische Klinik und Poliklinik (Kardiologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Klinische Chemie und Pathobiochemie
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