In 105 patients with type 2 diabetes and in 62 controls, including subgroups with vs. without hypertension, cardiac function and vascular function were assessed by tissue Doppler and the new wave intensity approach. The diabetes group had diminished myocardial velocities, increased myocardial oxygen consumption, stiffer central arteries and increased wave intensity peak W1. Accordingly in diabetics, an increased amount of energy is transferred into the vascular system by each pulse wave despite a subclinical myocardial dysfunction. Given the well known reduction of myocardial perfusion and mitochondrial energy production in the diabetic heart, this constellation is associated with the risk of myocardial energy depletion.
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In 105 patients with type 2 diabetes and in 62 controls, including subgroups with vs. without hypertension, cardiac function and vascular function were assessed by tissue Doppler and the new wave intensity approach. The diabetes group had diminished myocardial velocities, increased myocardial oxygen consumption, stiffer central arteries and increased wave intensity peak W1. Accordingly in diabetics, an increased amount of energy is transferred into the vascular system by each pulse wave despite...
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